EpiCalsome™: Our next-Generation Electrolyte Solution
Electrolytes such as calcium, magnesium, potassium, and sodium are emerging as key ingredients in modern skincare.
Valued for their ability to boost hydration, electrolytes strengthen the skin barrier, and improve overall skin resilience. By helping to regulate moisture balance and support water transport within the skin, electrolytes contribute to a smoother, plumper, and healthier-looking complexion. In addition, they enhance the performance of other active ingredients—such as hyaluronic acid, peptides, and vitamins—making them highly effective in multifunctional skincare formulations.
Among these, calcium plays a central role in skin barrier function and epidermal renewal. A balanced calcium gradient is essential for keratinocyte differentiation, lipid organization, and overall skin homeostasis. However, this natural balance is often disrupted by aging, environmental stress, and metabolic conditions such as diabetes, leading to weakened barrier integrity, dehydration, increased sensitivity, and slower skin recovery. As a result, there is growing demand for advanced skincare solutions that not only hydrate but also restore underlying biological processes and support long-term skin health.
EpiCalsome™ addresses this need with a breakthrough approach to calcium delivery in skincare. Unlike conventional formulations, EpiCalsome™ is designed to maximize calcium bioavailability by encapsulating calcium ions in high-quality phospholipids. This advanced delivery system enables efficient penetration and release into the skin, helping to replenish calcium levels and restore the physiological gradient critical for a strong and healthy skin barrier.
At the core of this innovation is a proprietary, patent-pending, double-cone vector technology, which optimizes the delivery of bioavailable calcium for both immediate and long-term benefits.
The superiority of this system has been clearly demonstrated in a human reconstructed epidermis model: neither calcium nor phospholipids (lecithin) alone were able to restore proper epidermal differentiation and barrier formation under low-calcium conditions. Treatment with calcium chloride even further impaired epidermal structure, while phospholipids alone failed to rescue loricrin expression. In contrast, only their combination within the double‑cone vector system (EpiCalsome™) successfully restored a dense, fully stratified epidermis and significantly increased loricrin expression—a key protein essential for the formation of a functional skin barrier. These findings highlight the critical synergy between calcium and phospholipids when delivered through the optimized double‑cone vector structure.
In addition, EpiCalsome™ has been shown to enhance the expression of key barrier proteins and accelerate recovery after irritation. This makes it particularly suitable for stressed, aging, and sensitive skin, as well as skin affected by metabolic imbalances.
In a rapidly growing market for barrier repair, hydration, and sensitive skin care, EpiCalsome™ stands out as a high-performance active. By combining the proven benefits of electrolytes with an innovative delivery technology, it unlocks the full potential of calcium in skincare—offering a powerful solution for stronger, more resilient, and visibly healthier skin.
Rescuing of Epidermis Stratification
Innovative Calcium Double Cone Vector System:
