Role of Beta-Endorphin in the Skin
D. Schmid and F. Zuelli
SÖFW-Journal (131) 4, (2005)
Betaendorphin is a peptide neurotransmitter that is mainly produced in the central nerve system where it causes an analgesic effect and a feeling of euphoria after binding to opiate receptors. During the last years several research groups confirmed the presence of a fully functional betaendorphin/muopiate receptor system in a variety of cutaneous cell types. The endorphin/muopiate receptor system was shown to modulate migration of keratinocytes and to be involved in wound healing. Chaste tree, a medicinal plant indigenous to the Mediterranean region and Asia was shown to produce lipophilic substances that bind to the muopiate receptor and to stimulate betaendorphin production in vivo. Topical application of a preparation of the lipophilic fraction of chaste tree berries was found to exert a positive effect on skin hydration, firmness and wrinkle depth.
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D. Schmid and F. Zuelli
SÖFW-Journal (131) 4, (2005)
Betaendorphin is a peptide neurotransmitter that is mainly produced in the central nerve system where it causes an analgesic effect and a feeling of euphoria after binding to opiate receptors. During the last years several research groups confirmed the presence of a fully functional betaendorphin/muopiate receptor system in a variety of cutaneous cell types. The endorphin/muopiate receptor system was shown to modulate migration of keratinocytes and to be involved in wound healing. Chaste tree, a medicinal plant indigenous to the Mediterranean region and Asia was shown to produce lipophilic substances that bind to the muopiate receptor and to stimulate betaendorphin production in vivo. Topical application of a preparation of the lipophilic fraction of chaste tree berries was found to exert a positive effect on skin hydration, firmness and wrinkle depth.
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