Preparation and Properties of Coenzyme Q10 Nanoemulsions
F. Zuelli, E. Belser, D. Schmid, Ch. Liechti, F. Suter
Cosmetic Science Technology: 40 - 46 (2006)
Coenzyme Q10 (CoQ10), also known as ubiquinone, is used for energy production within cells and acts as and antioxidant. Due to this dual function CoQ10 finds its application in different commercial branches such as drugs, food supplements, or cosmetics.
Since CoQ10 is highly lipophilic, the topical and oral bioavailability is very low. Several attempts have been made to improve absorption. Latest technical developments reveal that encapsulation of CoQ10 in nanoemulsions results in a significantly enhanced bioavailability. In addition, multiple nanoemulsions prepared according to a patented process even allow the administration of several incompatible substances at the same time.
This article gives an overview of current key developments of the encapsulation of CoQ10 in nanoemulsions. It highlights how encapsulation upgrades the bioavailability of CoQ10 and with this the efficacy of CoQ10. In addition, this article presents latest in vitro tests demonstrating the influence of CoQ10 on the synthesis of collagen I and on the activity of mitochondria and their resistance against stress of dermal fibroblasts and keratinocytes, respectively.
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F. Zuelli, E. Belser, D. Schmid, Ch. Liechti, F. Suter
Cosmetic Science Technology: 40 - 46 (2006)
Coenzyme Q10 (CoQ10), also known as ubiquinone, is used for energy production within cells and acts as and antioxidant. Due to this dual function CoQ10 finds its application in different commercial branches such as drugs, food supplements, or cosmetics.
Since CoQ10 is highly lipophilic, the topical and oral bioavailability is very low. Several attempts have been made to improve absorption. Latest technical developments reveal that encapsulation of CoQ10 in nanoemulsions results in a significantly enhanced bioavailability. In addition, multiple nanoemulsions prepared according to a patented process even allow the administration of several incompatible substances at the same time.
This article gives an overview of current key developments of the encapsulation of CoQ10 in nanoemulsions. It highlights how encapsulation upgrades the bioavailability of CoQ10 and with this the efficacy of CoQ10. In addition, this article presents latest in vitro tests demonstrating the influence of CoQ10 on the synthesis of collagen I and on the activity of mitochondria and their resistance against stress of dermal fibroblasts and keratinocytes, respectively.
download pdf
